COX-2-specific inhibitors in clinical practice: Why did Rofecoxibfail?

COX-2-specific inhibitors in clinical practice: Why did Rofecoxibfail?
Total words is 1500 (it’s important no more than 1550 words)
COX-2-specific inhibitors in clinical practice: Why did Rofecoxib fail?
Assignment description:
Describe mechanism of action of COX2 specific inhibitors and rationale for their development and use. Discuss the reason (s) for the removal of one of the COX2 inhibitors (Rofecoxib) from the drug market.
Design of assignment:
introduction(150 words)
body max is (1300 words)
Conclusion (50 words max)
Summary 150 words max(strictly) -this would be well explained on a paper I will attach later
References from 8-10 and must be peer reviewed. You can put 2 or 3 from other high quality resources
make sure no spiling or grammar mistakes please.